Effects of dietary salt restriction on puromycin aminonucleoside nephrosis
نویسندگان
چکیده
منابع مشابه
Effects of Dietary Salt Restriction on Puromycin Aminonucleoside Nephrosis: Preliminary Data
Proteinuria is a major promoter that induces tubulointerstitial injury in glomerulopathy. Dietary salt restriction may reduce proteinuria, although the mechanism is not clear. We investigated the effects of dietary salt restriction on rat kidneys in an animal model of glomerular proteinuria. Male Sprague-Dawley rats were used and divided into 3 groups: vehicle-treated normal-salt controls, puro...
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Increased expression of osteopontin (OPN) associated with interstitial monocyte infiltration has been demonstrated in the early phase of a variety of experimental renal diseases. Whether these changes occur in the chronic phase of progressive glomerular disease is unknown. Chronic puromycin aminonucleoside nephrosis (PAN) was induced in 16 rats by the injection of a single bolus of PA into the ...
متن کاملUltrastructural study on nephrin expression in experimental puromycin aminonucleoside nephrosis.
BACKGROUND Nephrin is a recently identified protein that is a key component of the slit diaphragm. This protein may play a crucial role in maintaining the glomerular filtration barrier, and mutations in the gene for nephrin reportedly lead to congenital nephrosis. However, the expression of nephrin in acquired glomerular disease has not yet been fully clarified. To address this issue, we analys...
متن کاملUltrastructural study on nephrin expression in puromycin aminonucleoside nephrosis
Background. Nephrin is a recently identified protein that is a key component of the slit diaphragm. This protein may play a crucial role in maintaining the glomerular filtration barrier, and mutations in the gene for nephrin reportedly lead to congenital nephrosis. However, the expression of nephrin in acquired glomerular disease has not yet been fully clarified. To address this issue, we analy...
متن کاملMitochondrial dysfunction in focal segmental glomerulosclerosis of puromycin aminonucleoside nephrosis.
Focal segmental glomerular sclerosis (FSGS) is a major renal complication of mitochondrial (mt) cytopathies. The present study was designed to investigate the possibility of mtDNA lesion accumulation in podocytes, which are a primary pathogenic site of FSGS, during the development of glomerulopathy in puromycin aminonucleoside nephrosis (PAN). Two renal pathological phases of PAN, nephrosis pha...
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ژورنال
عنوان ژورنال: Kidney Research and Clinical Practice
سال: 2012
ISSN: 2211-9132
DOI: 10.1016/j.krcp.2012.04.436